Increased weight gain after ovariectomy is not a consequence of leptin resistance.

  title={Increased weight gain after ovariectomy is not a consequence of leptin resistance.},
  author={Yun-fei Chen and Mark L. Heiman},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={280 2},
The positive correlation between leptin and body fat mass has caused some investigators to speculate that leptin resistance contributes to obesity. Loss of ovarian function in human and rat is associated with increased fat mass gain and increased circulating leptin levels. To study whether ovariectomy produces leptin resistance, Sprague-Dawley female rats were ovariectomized or sham operated and injected with leptin for 35 days. Ovariectomy (OVX) produced hyperphagia and increased gain in both… CONTINUE READING
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  • I Cusin, J Rouru, KE Zakrzewska, B Jeanrenaud, F. Rohner-Jeanrenaud
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