Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1.


BACKGROUND Many studies link depression to an increase in the excitatory-inhibitory ratio in the forebrain. Presynaptic alterations in a shared pathway of the glutamate/gamma-aminobutyric acid (GABA) cycle may account for this imbalance. Evidence suggests that decreased vesicular glutamate transporter 1 (VGLUT1) levels in the forebrain affect the glutamate… (More)
DOI: 10.1016/j.biopsych.2009.02.027


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