Increased vulnerability to β-cell destruction and diabetes in mice lacking NAD(P)H:quinone oxidoreductase 1.

@article{Yeo2013IncreasedVT,
  title={Increased vulnerability to β-cell destruction and diabetes in mice lacking NAD(P)H:quinone oxidoreductase 1.},
  author={Seung-Hoon Yeo and J G Noh and Yong-Hoon Kim and G T Gang and Sang-Woo Kim and Kyoung-Shim Kim and Jung Hwan Hwang and Minho Shong and Chul-Ho Lee},
  journal={Toxicology letters},
  year={2013},
  volume={219 1},
  pages={35-41}
}
NAD(P)H:quinone oxidoreductase 1 (NQO1) has been known to protect cells against stressors, including the diabetogenic reagent streptozotocin (STZ). The present study demonstrated that NQO1 deficiency resulted in increased pancreatic β-cell death induced by multiple low dose of STZ (MLDS) injections. NQO1 knockout (KO) mice showed hyperglycemia, body weight loss, impaired glucose clearance rate and a lower plasma insulin level after MLDS treatment. Moreover, β-cell mass and pancreatic insulin… CONTINUE READING
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