Increased vulnerability of neonatal rats and mice to 1-nitronaphthalene-induced pulmonary injury.

@article{Fanucchi2004IncreasedVO,
  title={Increased vulnerability of neonatal rats and mice to 1-nitronaphthalene-induced pulmonary injury.},
  author={Michelle V. Fanucchi and Kimberly C Day and Candice C. Clay and Charles G. Plopper},
  journal={Toxicology and applied pharmacology},
  year={2004},
  volume={201 1},
  pages={53-65}
}
The postnatal period of lung development is a critical window of susceptibility to environmental toxicants, including polyaromatic hydrocarbons (PAHs) and furans. To determine whether the increased susceptibility of neonatal lung injury due to environmental toxicants is a universal response across species and also applies to nitrated compounds, adult and 7-day-old male mice and rats were given a single intraperitoneal dose (0, 12.5, 25, 50, or 100 mg/kg) of 1-nitronaphthalene and killed 24 h… CONTINUE READING

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