Increased vitamin A in esophagus and other extrahepatic tissues after chronic ethanol consumption in the rat.

@article{Leo1986IncreasedVA,
  title={Increased vitamin A in esophagus and other extrahepatic tissues after chronic ethanol consumption in the rat.},
  author={Maria Anna Leo and C. I. Kim and Charles S. Lieber},
  journal={Alcoholism, clinical and experimental research},
  year={1986},
  volume={10 5},
  pages={
          487-92
        }
}
In rats fed ethanol (36% of total energy) for 1 month, vitamin A content of the esophageal mucosa was found to be increased 5-fold, compared to animals pair-fed an isocaloric control diet containing the same amount of vitamin A. Similar results were observed with diets of either lower vitamin A content or zinc supplementation. Significant increases of retinoids were also found in lungs, trachea, kidneys, and testes, but not in the eyes. These increases in extrahepatic tissues contrasted… 
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Citation Type

Effect of ethanol and vitamin A deficiency on epithelial cell proliferation and structure in the rat esophagus.
Effects of ethanol and carbon tetrachloride upon vitamin A status of rats.
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CCl4 (with phenobarbitol), which is a more potent hepatotoxin as evidenced by a more elevated cytochrome P450 and distorted liver morphology, not only reduced liver vitamin A, but also increased serum vitamin A.
Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed rats.
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It is suggested that chlormethiazole can restore both hepatic retinol and retinyl ester concentrations to normal levels in ethanol-fed rats through blocking enhanced both degradation of vitamin A and mobilization of Vitamin A from the liver into the circulation.
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TLDR
It is concluded that liver plasma membranes contain a significant amount of vitamin A, that vitamin A supplementation increases membrane fluorescence polarization and that chronic ethanol administration can interfere with this effect.
Differential effects of retinoids and chronic ethanol consumption on membranes in rats.
TLDR
Increased sialic acid concentration has been incriminated in the pathogenesis of tumor development, it may provide a mechanism whereby lowered hepatic vitamin A promotes carcinogenesis and retinoic acid feeding opposes this process.
The Effect of Maternal Ethanol Ingestion on Fetal Vitamin A in the Rat
TLDR
The ingestion of ethanol by pregnant rats is associated with a reduction in fetal liver vitamin A levels and an elevation in the levels of lung and kidney vitamin A, indicating possible altered vitamin A metabolism as a result of ethanol consumption.
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TLDR
It was concluded that low-dose ATRA treatment could restore retinoids concentrations and abolish the PRM formation in liver of ALD rats, and then ameliorate the injury of liver cells.
Low-dose ATRA supplementation abolishes PRM formation in rat liver and ameliorates ethanol-induced liver injury
  • Zhihong Pan, Z. Dan, Yu Fu, Wang-xian Tang, Ju-sheng Lin
  • Medicine, Biology
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
  • 2006
TLDR
It was concluded that low-dose ATRA treatment could restore retinoids concentrations and abolish the PRM formation in liver of ALD rats, and then ameliorate the injury of liver cells.
Hepatic, metabolic and toxic effects of ethanol: 1991 update.
  • C. Lieber
  • Medicine, Biology
    Alcoholism, clinical and experimental research
  • 1991
Until two decades ago, dietary deficiencies were considered to be the only reason for alcoholics to develop liver disease. As the overall nutrition of the population improved, more emphasis was…
Centrilobular distribution of acetaldehyde and collagen in the ethanol‐fed micropig
TLDR
Histological and immunofluorescent studies provide in vivo evidence that perivenous collagen deposition is linked to ethanol metabolism and acetaldehyde production, and produced the features of alcoholic liver disease concurrent with hepatic deficiency of selected nutrients.
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References

SHOWING 1-10 OF 20 REFERENCES
Hepatic vitamin A depletion after chronic ethanol consumption in baboons and rats.
TLDR
It is concluded that chronic ethanol consumption decreases hepatic vitamin A, and that some mechanisms other than malnutrition and malabsorption may be involved in this process.
Hepatotoxicity of vitamin A and ethanol in the rat.
Changes in vitamin A status after acute ethanol administration in the rat.
TLDR
An acute dose of ethanol increases serum vitamin A and decreases hepatic vitamin A, most likely because of increased release from the liver or decreased uptake by the liver of retinyl esters as part of the lipoproteins.
Effect of hepatic vitamin A depletion on the liver in humans and rats.
Effect of chronic alcohol consumption and moderate fat diet on vitamin A status in rats fed either vitamin A or β-carotene
TLDR
It is concluded that alcohol consumption results in decreased hepatic vitamin A storage, which is not due to the malabsorption of either retinyl acetate or beta-carotene, or to altered activities of several enzymes involved in ethanol and vitamin A metabolism.
The feeding of alcohol in liquid diets: two decades of applications and 1982 update.
TLDR
Variations of the liquid diet formulation are compared and three standardized basic formulas are being proposed for the rat, suitable for most experimental applications, particularly those intended to mimic the clinical situation in which the various effects of alcohol occur in the setting of liver changes characterized by a fatty liver.
Retinol and retinyl esters in parenchymal and nonparenchymal rat liver cell fractions after long-term administration of ethanol.
TLDR
It is suggested that liver retinoid metabolism may be increased, after it was demonstrated that liver uptake of chylomicron retinyl ester is not impaired in the ethanol-fed rat, and the concentrations of unesterified retinol and retinyl oleate were increased.
Enhanced pulmonary and intestinal activation of procarcinogens and mutagens after chronic ethanol consumption in the rat
TLDR
It is investigated, as a possible contributing factor to carcinogenesis in this population, the effect of chronic ethanol consumption on metabolic activation of procarcinogens by microsomes isolated from lungs and small intestine.
Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption.
TLDR
The ability of ethanol to increase the rate ofDMN metabolism over such a broad range of DMN concentrations is in marked contrast to the effects of other microsomal enzyme inducers, such as phenobarbital and 3-methylcholanthrene.
Retinoic acid metabolism by a system reconstituted with cytochrome P-450.
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