Increased viscosity is protective for arteriolar endothelium and microvascular perfusion during severe hemodilution in hamster cheek pouch.

@article{Bertuglia2001IncreasedVI,
  title={Increased viscosity is protective for arteriolar endothelium and microvascular perfusion during severe hemodilution in hamster cheek pouch.},
  author={Silvia Bertuglia},
  journal={Microvascular research},
  year={2001},
  volume={61 1},
  pages={56-63}
}
We hypothesized that during severe hemodilution (SH), i.e., hemodilution beyond 50%, the reduced conditions of shear stress result in endothelium dysfunction and subsequent vasoconstriction. To evaluate the endothelial responses associated with the reduction of hematocrit we tested the responsiveness of arterioles to acetylcholine. Infusion with high-molecular-weight dextran 500,000 following SH was characterized by laser Doppler flowmetry (LDF), total perfused capillary length (TPCL), vessel… CONTINUE READING