Increased virulence of a fibronectin-binding protein mutant of Staphylococcus aureus in a rat model of pneumonia.

@article{McElroy2002IncreasedVO,
  title={Increased virulence of a fibronectin-binding protein mutant of Staphylococcus aureus in a rat model of pneumonia.},
  author={Mary C McElroy and David J. Cain and Christine Tyrrell and T. J. Foster and Christopher Haslett},
  journal={Infection and immunity},
  year={2002},
  volume={70 7},
  pages={3865-73}
}
Fibronectin-binding proteins mediate Staphylococcus aureus internalization into nonphagocytic cells in vitro. We have investigated whether fibronectin-binding proteins are virulence factors in the pathogenesis of pneumonia by using S. aureus strain 8325-4 and isogenic mutants in which fibronectin-binding proteins were either deleted (DU5883) or overexpressed [DU5883(pFnBPA4)]. We first demonstrated that fibronectin-binding proteins mediate S. aureus internalization into alveolar epithelial… CONTINUE READING

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