Increased virulence of Yersinia pseudotuberculosis by two independent mutations

  title={Increased virulence of Yersinia pseudotuberculosis by two independent mutations},
  author={Roland Rosqvist and Mikael Skurnik and Hans Wolf-Watz},
A chromosomally encoded protein, which mediates invasion into HeLa cells was recently identified in Yersinia pseudotuberculosis1,2. The role of this protein (invasin) in the virulence process was not, however, investigated. We show that mutation of the invasin gene in Y. pseudotuberculosis abolishes the ability of the bacteria to invade HeLa cells. When mice were challenged by intraperitoneal injection both the mutant and the wild-type strain produced infections of similar virulence but mutant… CONTINUE READING

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