Increased viral loads and exacerbated innate host responses in aged macaques infected with the 2009 pandemic H1N1 influenza A virus.

@article{Josset2012IncreasedVL,
  title={Increased viral loads and exacerbated innate host responses in aged macaques infected with the 2009 pandemic H1N1 influenza A virus.},
  author={Laurence Josset and Flora Engelmann and Kristen Haberthur and Sara Kelly and Byung Soon Park and Yoshi Kawoaka and Adolfo Garc{\'i}a-Sastre and Michael G. Katze and Ilhem Messaoudi},
  journal={Journal of virology},
  year={2012},
  volume={86 20},
  pages={11115-27}
}
In contrast to seasonal influenza virus infections, which typically cause significant morbidity and mortality in the elderly, the 2009 H1N1 virus caused severe infection in young adults. This phenomenon was attributed to the presence of cross-protective antibodies acquired by older individuals during previous exposures to H1N1 viruses. However, this hypothesis could not be empirically tested. To address this question, we compared viral replication and the development of the immune response in… CONTINUE READING
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