Increased vascularization in mice overexpressing angiopoietin-1.

  title={Increased vascularization in mice overexpressing angiopoietin-1.},
  author={Chitra Suri and Joyce McClain and Gavin Thurston and D M Mcdonald and Hu Zhou and E H Oldmixon and Thomas N Sato and George D. Yancopoulos},
  volume={282 5388},
The angiopoietins and members of the vascular endothelial growth factor (VEGF) family are the only growth factors thought to be largely specific for vascular endothelial cells. Targeted gene inactivation studies in mice have shown that VEGF is necessary for the early stages of vascular development and that angiopoietin-1 is required for the later stages of vascular remodeling. Here it is shown that transgenic overexpression of angiopoietin-1 in the skin of mice produces larger, more numerous… CONTINUE READING
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