Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension.

@article{Sehgel2013IncreasedVS,
  title={Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension.},
  author={Nancy Lisa Sehgel and Yi Zhu and Zhe Sun and Jerome P. Trzeciakowski and Zhongkui Hong and William Curt Hunter and Dorothy E. Vatner and Gerald A. Meininger and Stephen F. Vatner},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2013},
  volume={305 9},
  pages={H1281-7}
}
Increased vascular stiffness is fundamental to hypertension, and its complications, including atherosclerosis, suggest that therapy should also be directed at vascular stiffness, rather than just the regulation of peripheral vascular resistance. It is currently held that the underlying mechanisms of vascular stiffness in hypertension only involve the extracellular matrix and endothelium. We hypothesized that increased large-artery stiffness in hypertension is partly due to intrinsic mechanical… CONTINUE READING
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