Increased vascular selectivity and prolonged pharmacological efficacy of the L-type Ca2+ channel antagonist lercanidipine in human cardiovascular tissue.

@article{Brixius2005IncreasedVS,
  title={Increased vascular selectivity and prolonged pharmacological efficacy of the L-type Ca2+ channel antagonist lercanidipine in human cardiovascular tissue.},
  author={Klara Brixius and Thomas L. Gross and Paschalios Tossios and H. Geissler and Uwe Mehlhorn and Robert H. G. Schwinger and Khosro Hekmat},
  journal={Clinical and experimental pharmacology & physiology},
  year={2005},
  volume={32 9},
  pages={708-13}
}
1. The present study investigates the vasoselectivity of lercanidipine (LER), a 1,4-dihydropyridine calcium channel blocker, compared with amlodipine (AML) and nifedipine (NIF) in human cardiovascular tissue. Experiments were performed either in human left ventricular failing myocardium (orthotopic heart transplants) or in isolated right atrial trabeculae and isolated vessel preparations of arteria mammaria obtained from patients undergoing aortocoronary bypass operation. 2. The obtained rank… CONTINUE READING