Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin.

@article{Grode2005IncreasedVE,
  title={Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Gu{\'e}rin mutants that secrete listeriolysin.},
  author={Leander Grode and Peter Seiler and Sven Baumann and Jürgen Hess and Volker Brinkmann and Ali Nasser Eddine and Peggy Mann and Christian Goosmann and Silke Bandermann and Debbie A. Smith and Gregory J Bancroft and Jean-Marc Reyrat and Dick van Soolingen and Bärbel Raupach and Stefan H. E. Kaufmann},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 9},
  pages={
          2472-9
        }
}
The tuberculosis vaccine Mycobacterium bovis bacille Calmette-Guérin (BCG) was equipped with the membrane-perforating listeriolysin (Hly) of Listeria monocytogenes, which was shown to improve protection against Mycobacterium tuberculosis. Following aerosol challenge, the Hly-secreting recombinant BCG (hly+ rBCG) vaccine was shown to protect significantly better against aerosol infection with M. tuberculosis than did the parental BCG strain. The isogenic, urease C-deficient hly+ rBCG (DeltaureC… 

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