Increased urinary excretion of carnitine in patients treated with cisplatin

  title={Increased urinary excretion of carnitine in patients treated with cisplatin},
  author={Wolfgang Heuberger and Simona Berardi and Emanuel Jacky and Pascalline Pey and Stephan Kr{\"a}henb{\"u}hl},
  journal={European Journal of Clinical Pharmacology},
AbstractObjective: To study the effect of cisplatin on plasma concentrations and urinary excretion of carnitine in ten patients with different malignancies treated with chemotherapy. Methods: Carnitine concentrations were determined using a radioenzymatic assay and other metabolites by routine methods of clinical chemistry. Renal clearances were calculated by dividing urinary excretions by the respective plasma concentrations. Results: Before treatment, all patients had a normal plasma… 

Urinary excretion of carnitine as a marker of proximal tubular damage associated with platin-based antineoplastic drugs.

  • M. HaschkeTanja Vitins S. Krähenbühl
  • Medicine, Biology
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2010
All platin derivatives investigated are associated with renal tubular damage in humans without significantly affecting glomerular function.

Dynamics of L-Carnitine in Plasma and Urine in Patients Undergoing Cisplatin Chemotherapy

CDDP transiently increased plasma LC levels, and the mechanism seemed to involve recruitment for marked urinary loss of LC, suggesting that the dynamics of LC were independent of preexisting physical parameters.

Serum Carnitine Levels in Childhood Leukemia

A significant transient decrease in the levels of carnitine during the treatment was observed in children with acute leukemia, and a statistically significant recovery was observed between phase B (end of intensive chemotherapy) and D (some years after the completion of treatment) for free and total carnitines.

Urinary excretion of l-carnitine and its short-chain acetyl-l-carnitine in patients undergoing carboplatin treatment

Treatment with carboplatin was associated with a marked urinary loss of LC and ALC, most likely due to inhibition of carnitine reabsorption in the kidney, and plasma concentrations and urinary excretion of glucose, phosphate and urea nitrogen and creatinine clearance, however, were not affected bycarboplatin therapy, indicating no impaired kidney function.

Increased urinary losses of carnitine during ifosfamide chemotherapy

Chloroacetaldehyde and thiodiglycolic acid, two metabolites of ifosfamide, interfere with mitochondrial function and may sequester carnitine, which might lead to symptomatic carnitines deficiency after several chemotherapy cycles.

Effect Of L-Carnitine On Urinary Il-18 And Gfr In Patient Receiving Cisplatin-Based Regimen

L-carnitine with their antioxidant, anti-inflammatory and to some extent antiapoptotic effects may have ameliorative effect on nephrotoxicity in patients that received cisplatin.

Role of carnitine in cancer chemotherapy-induced multiple organ toxicity.

  • M. Sayed-Ahmed
  • Biology, Medicine
    Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
  • 2010

Ameliorative Effect of L-Carnitine on Renal Function and Oxidative Stress in Cancer Patients with Cisplatin-Induced Nephrotoxicity

L-carnitine significantly ameliorated nephrotoxicity in patients receiving cisplatin primarily by inhibiting renal oxidative stress, and this study found this to be a major dose-limiting side effect facing cisPlatin-based chemotherapy of a wide variety of cancers.

Original Article Efficacy of L-carnitine on liver function in childrens under chemotherapy with acute lymphoblastic leukemia

A randomized, double-blind, placebo-controlled study to assess the role of L-Carnitine by evaluating the liver functions and found no significant differences in Alb and GGT in either group of patients treated with L-carnitin or placebo.

Progression of Cisplatin-Induced Nephrotoxicity in a Carnitine-Depleted Rat Model

Data from this study suggest that oxidative stress plays an important role in cisplatin-induced kidney damage; carnitine deficiency should be viewed as an additional risk factor and/or a mechanism in cisPlatin- induced renal dysfunction, and L-carnitine supplementation attenuates cisplarin-induced renal dysfunction.



Alterations of serum and urinary carnitine profiles in cancer patients: hypothesis of possible significance.

The increased clearance of acylcarnitine and excretion of large amounts of AIAC are proposed to be a response to chemotherapy and represent a loss of energy to the cancer patient.

Hypomagnesemia and renal magnesium wasting in patients treated with cisplatin.

  • M. LamD. Adelstein
  • Medicine
    American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1986

Renal tubular function in patients treated with high‐dose cisplatin

A good correlation was registered between the increase in urinary excretion rates of protein, NAG, and magnesium and the decrease in proximal tubular salt and water reabsorption during cisplatin administration.

Plasma and muscle free carnitine deficiency due to renal Fanconi syndrome.

In all 21 subjects with several different etiologies for the Fanconi syndrome, the mean fractional excretion of free carnitine as well as acyl carnite greatly exceeded normal values, which suggested that hepatic fatty acid oxidation was intact despite very low plasma free carnite levels.

The Renal Handling of Carnitine in Patients with Selective Tuhulopathy and with Fanconi Syndrome

It was concluded that the lowering of plasma carnitine in the patients with Fanconi syndrome was caused by excessive loss of carn itine in urine, and its pathophysiological significance remained to be established.

Carnitine metabolism in patients with chronic liver disease.

Patients with alcohol-induced cirrhosis have increased plasma carnitine concentrations, which may result from increased carnItine biosynthesis because of increased skeletal muscle protein turnover and the increase in the fractional carn itine excretion in patients with primary biliary Cirrhosis may result in competition of bile acids and/or bilirubin with tubular carnitines re absorption.

Comparison of methods of evaluating nephrotoxicity of cis‐platinum

These urinary proteins are sensitive indicators of proximal renal tubular injury and may provide greater sensitivity for comparison of the nephrotoxic potential of future platinum analogs or for assessing the efficacy of regimens designed to protect the kidney from platinum neph rotoxicity than other measurements.

A method for the determination of carnitine in the picomole range.