Increased uptake of quinine into the brain by inhibition of P-glycoprotein.

  title={Increased uptake of quinine into the brain by inhibition of P-glycoprotein.},
  author={Eric Pussard and Mourad Merzouk and Hubert Barennes},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  volume={32 2},
The impact of P-glycoprotein (P-gp) on the distribution of quinine between brain and plasma was studied experimentally in mice. Administration of quinine (20mg/kg, i.v.) to mdrla knockout mice resulted in enhanced brain concentrations of quinine as compared to the wild-type mice (7.9+/-1.4 microg/g versus 1.6+/-0.8 microg/g, respectively). Quinine concentrations and quinine-to-3-hydroxyquinine ratio in plasma were similar in normal and P-gp-deficient mice. The effect of intravenously… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…