Increased uptake of oxidized LDL by macrophages from type 2 diabetics is inhibited by polyamines.

Abstract

The aim of this study was to evaluate the effect of polyamines putrescine, spermidine and spermine on human LDL oxidation and to assess the ability of macrophages derived from type 2 diabetic patients to uptake oxLDL. Polyamine effect was compared with α-tocopherol. Four healthy subjects and eight type 2 diabetic patients were included in this study. To… (More)
DOI: 10.1016/j.biopha.2015.11.006

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