Increased uptake of oxLDL does not exert lipotoxic effects in insulin-secreting cells.

@article{Ma2019IncreasedUO,
  title={Increased uptake of oxLDL does not exert lipotoxic effects in insulin-secreting cells.},
  author={Zaijun Ma and Daniel F. J. Ketelhuth and Tina Wirstr{\"o}m and Tsuyoshi Ohki and Maria J Forteza and Hai-ning Wang and Vittorio Grill and Claes B Wollheim and Alf Bj{\"o}rklund},
  journal={Journal of molecular endocrinology},
  year={2019},
  volume={62 4},
  pages={
          159-168
        }
}
Modified lipoproteins can negatively affect beta cell function and survival. However, the mechanisms behind interactions of modified lipoproteins with beta cells - and in particular, relationships to increased uptake - are only partly clarified. By over-expressing the scavenger receptor CD36 (Tet-on), we increased the uptake of fluorescent low-density modified lipoprotein (oxLDL) into insulin-secreting INS-1 cells. The magnitude of uptake followed the degree of CD36 over-expression. CD36 over… CONTINUE READING
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