Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan

@inproceedings{Fridell2009IncreasedUP,
  title={Increased uncoupling protein (UCP) activity in Drosophila
                        insulin-producing neurons attenuates insulin signaling and extends lifespan},
  author={Yih-Woei C. Fridell and Melissa Hoh and Orsolya Kr{\'e}neisz and Suzanne Hosier and Chengyi Chang and Dane Scantling and Daniel K Mulkey and Stephen L. Helfand},
  booktitle={Aging},
  year={2009}
}
To understand the role of mitochondrial uncoupling protein (UCP) in regulating insulin signaling and glucose homeostasis, we created transgenicDrosophila lines with targeted UCP expression in insulin producing cells (IPCs). Increased UCP activity in IPCs results in decreased steady state Ca(2+) levels in IPCs as well as decreased PI3K activity and increased FoxO nuclear localization in periphery. This reduced systemic insulin signaling is accompanied by a mild hyperglycemia and extended life… CONTINUE READING