Increased types I and III collagen and transforming growth factor-beta 1 mRNA and protein in hypertrophic burn scar.

@article{Zhang1995IncreasedTI,
  title={Increased types I and III collagen and transforming growth factor-beta 1 mRNA and protein in hypertrophic burn scar.},
  author={Kezhong Zhang and Warren Garner and Liz Cohen and J. Rodriguez and Sok Phan},
  journal={The Journal of investigative dermatology},
  year={1995},
  volume={104 5},
  pages={750-4}
}
Hypertrophic scar is the result of abnormal healing that often follows thermal injury. Hypertrophic scar is characterized by excessive dermal fibrosis and scarring. Five cases of human hypertrophic scar were compared with normal skin using in situ hybridization to localize mRNAs for procollagen types I and III and transforming growth factor-beta 1. Expression of type I procollagen and TGF-beta 1 were also examined with immunohistochemistry. The results demonstrated a significant increase in the… CONTINUE READING

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