Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function.

@article{Kren2007IncreasedTC,
  title={Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function.},
  author={Angelika Kren and Vanessa Baeriswyl and François Lehembre and Christoph Wunderlin and Karin Strittmatter and Helena Antoniadis and Reinhard F{\"a}ssler and Ugo Cavallaro and Gerhard Christofori},
  journal={The EMBO journal},
  year={2007},
  volume={26 12},
  pages={
          2832-42
        }
}
Integrins are transmembrane receptors that bind extracellular matrix proteins and enable cell adhesion and cytoskeletal organization, as well as transduction of signals into cells, to promote various aspects of cellular behavior, such as proliferation or survival. Integrins participate in many aspects of tumor biology. Here, we have employed the Rip1Tag2 transgenic mouse model of pancreatic beta cell carcinogenesis to investigate the role of beta(1)-integrin in tumor progression. Specific… CONTINUE READING
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