Increased transversions in a novel mutator colon cancer cell line

@article{Eshleman1998IncreasedTI,
  title={Increased transversions in a novel mutator colon cancer cell line},
  author={James R. Eshleman and Preston Scott Donover and Susan J Littman and Sandra E Swinler and Guo-Min Li and James D. Lutterbaugh and James K. V. Willson and Paul Modrich and W. David Sedwick and Sanford D Markowitz and Martina Veigl},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={1125-1130}
}
We describe a novel mutator phenotype in the Vaco411 colon cancer cell line which increases the spontaneous mutation rate 10–100-fold over background. This mutator results primarily in transversion base substitutions which are found infrequently in repair competent cells. Of the four possible types of transversions, only three were principally recovered. Spontaneous mutations recovered also included transitions and large deletions, but very few frameshifts were recovered. When compared to known… CONTINUE READING

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