Increased transmitter release at excitatory synapses produced by direct activation of adenylate cyclase in rat hippocampal slices.

@article{ChavezNoriega1994IncreasedTR,
  title={Increased transmitter release at excitatory synapses produced by direct activation of adenylate cyclase in rat hippocampal slices.},
  author={Laura E. Chavez-Noriega and Charles F. Stevens},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1994},
  volume={14 1},
  pages={310-7}
}
The field EPSP recorded in the CA1 region of rat hippocampal slices is potentiated by bath application of the direct adenylate cyclase activator forskolin (Chavez-Noriega and Stevens, 1992a). We have now used the whole-cell patch-clamp technique to analyze the effect of forskolin on evoked synaptic currents and on spontaneous and miniature excitatory postsynaptic currents (sEPSCs and mEPSCs) recorded in rat hippocampal slices in order to determine the relative contributions of pre- and… CONTINUE READING