Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.

@article{Chang1993IncreasedTG,
  title={Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.},
  author={Hui Li Chang and Nancy A. Gillett and Irene Figari and Ana Rodriguez Lopez and Michael A Palladino and Rik Derynck},
  journal={Cancer research},
  year={1993},
  volume={53 18},
  pages={4391-8}
}
Several observations correlate increased expression of transforming growth factor (TGF) beta 1 with tumorigenesis, suggesting that expression of this multifunctional growth factor may provide an advantage in tumor formation. However, many tumor cells are inhibited in their proliferation by TGF-beta in vitro, thus suggesting that TGF-beta synthesis could exert an antiproliferative effect on tumor formation. To evaluate the physiological relevance of increased TGF-beta 1 synthesis in such tumor… CONTINUE READING

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