Increased transendothelial migration of scleroderma lymphocytes.

Abstract

BACKGROUND CD4+ T lymphocytes play an important part in the pathogenesis of scleroderma (systemic sclerosis, SSc) and predominate in perivascular SSc skin lesions. Both soluble and membrane bound adhesion molecules are overexpressed in SSc, possibly influencing lymphocyte/endothelial cell (EC) contact. OBJECTIVE To assess the transendothelial migration… (More)

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