Increased transcription of immune and metabolic pathways in naive and allergic mice exposed to diesel exhaust.

@article{Stevens2008IncreasedTO,
  title={Increased transcription of immune and metabolic pathways in naive and allergic mice exposed to diesel exhaust.},
  author={Tina Stevens and Quentin Todd Krantz and William P. Linak and Susan Hester and M Ian Gilmour},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={102 2},
  pages={359-70}
}
Diesel exhaust (DE) has been shown to enhance allergic sensitization in animals following high-dose instillation or chronic inhalation exposure scenarios. The purpose of this study was to determine if short-term exposures to diluted DE enhance allergic immune responses to antigen, and identify possible mechanisms using microarray technology. BALB/c mice were exposed to filtered air or diluted DE to yield particle concentrations of 500 or 2000 mug/m(3) 4 h/day on days 0-4. Mice were immunized… CONTINUE READING