Increased tight junctional permeability is associated with the development of colon cancer.

@article{Soler1999IncreasedTJ,
  title={Increased tight junctional permeability is associated with the development of colon cancer.},
  author={Alejandro Peralta Soler and Rodney D. Miller and Kathleen V. Laughlin and Ned Z. Carp and David M. Klurfeld and James M Mullin},
  journal={Carcinogenesis},
  year={1999},
  volume={20 8},
  pages={
          1425-31
        }
}
Epithelial tissues act as barriers between two fluid compartments, and the epithelial barrier function is provided by the epithelial cells and the tight junctions (TJs) that connect them. We have shown previously that chronic treatment of a cultured epithelial monolayer with phorbol ester tumor promoters induces an increase in transepithelial paracellular permeability and produces tumor-like polyps, suggesting an association between TJ permeability and tumor formation. In this study, we… CONTINUE READING

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