Increased throughput in quantitative bioanalysis using parallel-column liquid chromatography with mass spectrometric detection.

@article{Jemal2001IncreasedTI,
  title={Increased throughput in quantitative bioanalysis using parallel-column liquid chromatography with mass spectrometric detection.},
  author={Mohammed Jemal and M Huang and Yan Mao and Daisy Whigan and M. Luann Powell},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2001},
  volume={15 12},
  pages={994-9}
}
The feasibility of quantitative bioanalysis by parallel-column liquid chromatography in conjunction with a conventional single-source electrospray mass spectrometer has been investigated using plasma samples containing a drug and its three metabolites. Within a single chromatographic run time, sample injections were made alternately onto each of two analytical columns in parallel at specified intervals, with a mass spectrometer data file opened at every injection. Thus, the mass spectrometer… CONTINUE READING

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