Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice.

Abstract

To explore the effect(s) of growth hormone signaling on thrombosis, we studied signal transduction and transcription factor 5 (STAT5)-deficient mice and found markedly reduced survival in an in vivo thrombosis model. These findings were not explained by a compensatory increase in growth hormone secretion. There was a modest increase in the activity of… (More)
DOI: 10.1182/blood-2010-06-292227

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