Increased thrombin activity after allergen challenge: a potential link to airway remodeling?

  title={Increased thrombin activity after allergen challenge: a potential link to airway remodeling?},
  author={Masaki Terada and Elizabeth A Kelly and Nizar N Jarjour},
  journal={American journal of respiratory and critical care medicine},
  volume={169 3},
In addition to its central role in hemostasis, thrombin may play a role in inflammation and remodeling. To investigate the contribution of thrombin to allergic airway inflammation in asthma, we used an enzymatic assay to determine thrombin activity in bronchoalveolar lavage fluid obtained from 19 subjects with atopic asthma before (Day 0) and 48 hours after (Day 2) segmental bronchoprovocation with antigen. Thrombin activity increased from 0 (0, 2.9) on Day 1 to 41.1 (0.3, 75.6) U x 10(-3)/ml… CONTINUE READING
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Enhanced thrombin activity in allergic asthma: a potential link between airway inflammation and remodeling [abstract

M Terada, EA Kelly, NN. Jarjour
Am J Respir Crit Care Med 2003;167:A453 • 2003
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