Increased threshold for TCR-mediated signaling controls self reactivity of intraepithelial lymphocytes.

@article{Guehler1998IncreasedTF,
  title={Increased threshold for TCR-mediated signaling controls self reactivity of intraepithelial lymphocytes.},
  author={Sarah R. Guehler and Rosalynde J. Finch and Jeffrey A Bluestone and Terrence A. Barrett},
  journal={Journal of immunology},
  year={1998},
  volume={160 11},
  pages={
          5341-6
        }
}
To examine the effect of self Ag on activation requirements of TCR-alphabeta intestinal intraepithelial lymphocytes (IELs), we utilized the 2C transgenic (Tg) mouse model specific for a peptide self Ag presented by class I MHC, H-2Ld. CD8alpha alpha and CD4-CD8- IELs from syngeneic (H-2b, self Ag-) and self Ag-bearing (H-2b/d, self Ag+) strains were examined for their ability to respond in vitro to P815 (H-2d) cell lines expressing the endogenous antigenic peptide, p2Ca. Proliferation, cytokine… CONTINUE READING

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