Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress.

@article{Mougiakakos2011IncreasedTP,
  title={Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress.},
  author={Dimitrios Mougiakakos and Carl Christian Johansson and Regina Jitschin and Martin B{\"o}ttcher and Rolf Kiessling},
  journal={Blood},
  year={2011},
  volume={117 3},
  pages={857-61}
}
Levels of regulatory T cells (Tregs) are increased in different cancer types as well as in inflammatory diseases, such as rheumatoid arthritis. Treg accumulation may result from aberrant proliferation and trafficking as well as greater resilience to oxidative stress compared with conventional T cells. This enhanced antioxidative capacity of Tregs possibly serves as feedback inhibition during inflammation and prevents uncontrolled immune reactions by favoring survival of suppressor rather than… CONTINUE READING
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