Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?

@article{Jensen2008IncreasedTI,
  title={Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?},
  author={Dalan R. Jensen and Leslie A. Knaub and John P. Konhilas and L. A. Leinwand and Paul S Maclean and Robert H Eckel},
  journal={Journal of lipid research},
  year={2008},
  volume={49 4},
  pages={870-9}
}
LPL is an enzyme involved in the breakdown and uptake of lipoprotein triglycerides. In the present study, we examined how the transgenic (Tg) overexpression of human LPL in mouse skeletal muscle affected tolerance to cold temperatures, cold-induced thermogenesis, and fuel utilization during this response. Tg mice and their nontransgenic controls were placed in an environmental chamber and housed in metabolic chambers that monitored oxygen consumption and carbon dioxide production with… CONTINUE READING
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