Increased systolic performance with diastolic dysfunction in adult spontaneously hypertensive rats.

@article{Cingolani2003IncreasedSP,
  title={Increased systolic performance with diastolic dysfunction in adult spontaneously hypertensive rats.},
  author={Oscar H. Cingolani and Xiao-Ping Yang and Maria A. Cavasin and Oscar A. Carretero},
  journal={Hypertension},
  year={2003},
  volume={41 2},
  pages={249-54}
}
Hypertensive heart disease is characterized by early development of hypertrophy and fibrosis that leads to heart failure (HF). HF develops in spontaneously hypertensive rats (SHR) after 18 months; however, it is not clear whether hypertrophy leads to altered cardiac performance at an earlier age in these rats. We studied cardiac performance in 10- to 11-month-old SHR and age-matched Wistar-Kyoto rats (WKY), using presssure-volume (PV) conductance catheter system to evaluate systolic and… CONTINUE READING
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