Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine.

@article{Jackson2002IncreasedSB,
  title={Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine.},
  author={Alan A. Jackson and Rebecca L. Dunn and Michael C Marchand and Simon C. Langley-Evans},
  journal={Clinical science},
  year={2002},
  volume={103 6},
  pages={633-9}
}
When rat dams consume a diet low in protein during pregnancy, their offspring develop high blood pressure. On a low-protein diet, the endogenous formation of the amino acid glycine is thought to become constrained. Glycine may become conditionally essential, as its rate of endogenous formation is inadequate to meet metabolic needs, and may be limiting for the normal development of the fetus. In the present study, five groups of Wistar rats were provided during pregnancy with one of five diets… CONTINUE READING