Increased susceptibility to urethane-induced lung tumors in mice with decreased expression of connexin43.

@article{Avanzo2004IncreasedST,
  title={Increased susceptibility to urethane-induced lung tumors in mice with decreased expression of connexin43.},
  author={Jos{\'e} Lu{\'i}s Avanzo and Marc Mesnil and Francisco Javier Hernandez-Blazquez and Ivone Isabel Mackowiak and Claudia M. C. Mori and Tereza Cristina da Silva and S{\'i}lvia Catarina Salgado Oloris and Ana Paula G{\'a}rate and Silvia Maria Gomes Massironi and Hiroshi Yamasaki and Maria L{\'u}cia Zaidan Dagli},
  journal={Carcinogenesis},
  year={2004},
  volume={25 10},
  pages={
          1973-82
        }
}
Gap junction intercellular communication capacity and connexin expression are reportedly decreased in human lung cancer. The mechanisms by which connexins, the gap junction proteins, act as tumor suppressors are unclear. In order to understand the involvement of connexins in tumorigenesis, we analyzed the effect of the heterologous deletion of Gja1 [the connexin43 (Cx43) gene] on the development of lung adenomas in mice. Heterozygous (Cx43(+/-)) and wild-type mice (Cx43(+/+)) were treated or… 
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Higher Incidence of Lung Adenocarcinomas Induced by DMBA in Connexin 43 Heterozygous Knockout Mice
TLDR
The experiment strengthens the evidence of the relationship between Connexin 43 deficiency and carcinogenesis and shows other organs showed a very similar cancer occurrence between Cx43 groups.
Altered expression of connexins in urethane-induced mouse lung adenomas.
Higher susceptibility of spontaneous and NNK‐induced lung neoplasms in connexin 43 deficient CD1 × AJ F1 mice: Paradoxical expression of connexin 43 during lung carcinogenesis
TLDR
It is indicated that Cx43 acts as a tumor suppressor gene in early lung tumorigenesis and loses this property in advanced carcinogenesis, and Cxs are better classified as conditional tumor suppressors.
Connexins as targets for cancer chemoprevention and chemotherapy.
Experimental Allergic Encephalomyelitis in Connexin 43–Heterozygous Mice
TLDR
An important role is suggested for gap-junctional intercellular communication in astrocytes in the recovery from CNS inflammation, and all heterozygous mice showed a striking increase in Cx43 expression during recovery, suggesting that the regulatory factors affecting C x43 expression are still present in mice that have only one wild-type Cx 43 allele.
Connexin43 Suppresses Lung Cancer Stem Cells
  • R. Ruch
  • Biology, Medicine
    Cancers
  • 2019
TLDR
It is demonstrated that Cx43 can reverse several neoplastic characteristics and reduce the abundance of human lung CSCs.
Connexin 43 Suppresses Lung Cancer Stem Cells
TLDR
It is demonstrated that Cx43 can reverse several neoplastic characteristics and reduce the abundance of human lung CSCs.
Altered intercellular communication in lung fibroblast cultures from patients with idiopathic pulmonary fibrosis
TLDR
The reduced Cx43 expression and the associated alteration in cell-to-cell communication may justify some of the known pathological characteristic of this devastating disease that still represents a challenge to the medical practice.
Deficiency of gap junction composed of connexin43 contributes to oxaliplatin resistance in colon cancer cells.
TLDR
It is concluded that the loss of GJ composed of Cx43 contributed to the resistance of oxaliplatin in colon cancer cells, and the mechanism was associated with intracellular ROS alternation.
Deletion of a single allele of Cx43 is associated with a reduction in the gap junctional intercellular communication and increased cell proliferation of mouse lung pneumocytes type II
Abstract.  Objectives: Connexins (Cx) are proteins that form the gap junctional channels at neighbouring plasma membranes between adjacent cells. Cxs are involved in cell communication, which is…
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References

SHOWING 1-10 OF 49 REFERENCES
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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