Increased susceptibility to systemic candidiasis in interleukin-6 deficient mice.

  title={Increased susceptibility to systemic candidiasis in interleukin-6 deficient mice.},
  author={Frank H J van Enckevort and Mihai G Netea and A. R. Hermus and C G J Fred Sweep and Jacques F Meis and Jos W M van der Meer and Bart Jan Kullberg},
  journal={Medical mycology},
  volume={37 6},
Interleukin-6 (IL-6) is a multifunctional cytokine that regulates multiple aspects of the innate immune response. It has been recently shown that endogenous IL-6 is crucial for an efficient defence against severe infections with Gram-negative and Gram-positive bacteria. The aim of the present study was to investigate the role of endogenous IL-6 in the defence against infection with the yeast Candida albicans. During experimental candidemia, IL-6 deficient mice (IL-6-/-) had a decreased survival… CONTINUE READING


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