Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement.

@article{Fischer1997IncreasedST,
  title={Increased susceptibility to endotoxin shock in complement C3- and C4-deficient mice is corrected by C1 inhibitor replacement.},
  author={Michael B. Fischer and Andrey P. Prodeus and Anne Nicholson-Weller and Minghe Ma and Jonathan R. Murrow and R R Reid and Henry B. Warren and Ana Lage and Francis D. Moore and Fred S. Rosen and Michael C Carroll},
  journal={Journal of immunology},
  year={1997},
  volume={159 2},
  pages={976-82}
}
Endotoxin shock is a life-threatening syndrome associated with a Gram-negative infection and mediated by a systemic inflammatory response. As a major effector of inflammation, the complement system has been implicated in both the pathogenesis and the protection from endotoxin shock. To clarify the role of complement in endotoxin shock, we have used mice totally deficient in either complement component C3 or C4. We found that both the C3- and C4-deficient mice were significantly more sensitive… CONTINUE READING