Increased susceptibility to activation and increased uptake of low density lipoprotein by cholesterol-loaded macrophages.

@article{Oiknine1992IncreasedST,
  title={Increased susceptibility to activation and increased uptake of low density lipoprotein by cholesterol-loaded macrophages.},
  author={J. Oiknine and M Aviram},
  journal={Arteriosclerosis and thrombosis : a journal of vascular biology},
  year={1992},
  volume={12 6},
  pages={745-53}
}
Inflammation is associated with macrophage activation, and this process has been shown to occur during atherogenesis. Macrophages (J774A.1) that were activated with either lipopolysaccharide (LPS), zymosan, or phorbol ester demonstrated a 30-35% increased uptake and degradation of low density lipoprotein (LDL) in comparison with nonactivated cells. This phenomenon was also shown for LDL cellular binding, and it resulted in macrophage cholesterol accumulation, as evidenced by cholesterol mass… CONTINUE READING
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