Increased susceptibility to SV40 transformation with development and in vitro aging.


The incidence of most cancers increases with aging. To examine whether this increased risk might be related to a higher susceptibility of older cells to neoplastic transformation, we transfected rat fibroblasts aged in vivo and in vitro with origin-defective SV40 DNA and measured the number of transformed foci. Substantial increases in the number of… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.