Increased susceptibility of ras-transformed cells to phenylacetate is associated with inhibition of p21ras isoprenylation and phenotypic reversion.

@article{Shack1995IncreasedSO,
  title={Increased susceptibility of ras-transformed cells to phenylacetate is associated with inhibition of p21ras isoprenylation and phenotypic reversion.},
  author={S Shack and Ling chun Chen and Alexandra C Miller and Romano Danesi and Dvorit Samid},
  journal={International journal of cancer},
  year={1995},
  volume={63 1},
  pages={124-9}
}
Alterations in the expression of ras oncogenes are characteristic of a wide variety of human neoplasms. Accumulating evidence has linked elevated ras expression with disease progression and with failure of tumors to respond to conventional therapies, including radiotherapy and certain chemotherapies. These observations led us to investigate the response of ras-transformed cells to the differentiation-inducer phenylacetate (PA). Using gene transfer models, we show that PA caused cytostasis in… CONTINUE READING

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