Increased susceptibility of human-PrP transgenic mice to bovine spongiform encephalopathy infection following passage in sheep.

@article{Plinston2011IncreasedSO,
  title={Increased susceptibility of human-PrP transgenic mice to bovine spongiform encephalopathy infection following passage in sheep.},
  author={Chris Plinston and Patricia Hart and Angela Chong and Nora Hunter and James Foster and Pedro Piccardo and Jean C Manson and Rona M. Barron},
  journal={Journal of virology},
  year={2011},
  volume={85 3},
  pages={1174-81}
}
The risk of the transmission of ruminant transmissible spongiform encephalopathy (TSE) to humans was thought to be low due to the lack of association between sheep scrapie and the incidence of human TSE. However, a single TSE agent strain has been shown to cause both bovine spongiform encephalopathy (BSE) and human vCJD, indicating that some ruminant TSEs are transmissible to humans. While the transmission of cattle BSE to humans in transgenic mouse models has been inefficient, indicating the… CONTINUE READING

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Comparative titration of experimental ovine BSE infectivity in sheep and mice.

The Journal of general virology • 2007
View 5 Excerpts
Highly Influenced

[A new variant of Creutzfeldt-Jakob disease].

Neurologia • 1997
View 8 Excerpts
Highly Influenced

Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties.

Proceedings of the National Academy of Sciences of the United States of America • 2010

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