Increased susceptibility of db/db mice to rosiglitazone-induced plasma volume expansion: role of dysregulation of renal water transporters.

@article{Zhou2013IncreasedSO,
  title={Increased susceptibility of db/db mice to rosiglitazone-induced plasma volume expansion: role of dysregulation of renal water transporters.},
  author={Li Jian Zhou and Gang Liu and Zhanjun Jia and Kevin T. Yang and Ying Sun and Yutaka Kakizoe and Mi Liu and Shufeng Zhou and Ren Wei Chen and Baoxue Yang and Tianxin Yang},
  journal={American journal of physiology. Renal physiology},
  year={2013},
  volume={305 10},
  pages={F1491-7}
}
Thiazolidinediones (TZDs), which are synthetic peroxisome proliferator-activated receptor subtype-γ (PPARγ), agonists are highly effective for treatment of type 2 diabetes. However, the side effect of fluid retention has significantly limited their application. Most of the previous studies addressing TZD-induced fluid retention employed healthy animals. The underlying mechanism of this phenomenon is still incompletely understood, particularly in the setting of disease state. The present study… CONTINUE READING