Increased susceptibility of a carrier of X-linked chronic granulomatous disease (CGD) to Aspergillus fumigatus infection associated with age-related skewing of lyonization

@article{RoesenWolff2001IncreasedSO,
  title={Increased susceptibility of a carrier of X-linked chronic granulomatous disease (CGD) to Aspergillus fumigatus infection associated with age-related skewing of lyonization},
  author={Angela Roesen-Wolff and W. Soldan and Klaus Heyne and Jakob Bickhardt and Manfred Gahr and Jochen Roesler},
  journal={Annals of Hematology},
  year={2001},
  volume={80},
  pages={113-115}
}
 Chronic granulomatous disease (CGD) is an inherited disorder characterized by the inability of phagocytes to generate normal amounts of superoxide (O2 –), leaving patients susceptible to life-threatening infections. It was previously assumed that once carriers of the X-linked form of CGD were found to have 30% or more of functionally normal neutrophils, they would be free of risk for infection because the lyonization ratio was believed to be constant. Our report strongly contradicts this… CONTINUE READING

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