Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity.

@article{Liu2010IncreasedSO,
  title={Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity.},
  author={Fang Liu and Sahoko Ichihara and William M Valentine and Ken Ichi Itoh and Masayuki Yamamoto and Sahabudeen Sheik Mohideen and Junzoh Kitoh and Gaku Ichihara},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2010},
  volume={115 2},
  pages={
          596-606
        }
}
1-Bromopropane (1-BP) was introduced as an alternative to ozone-depleting solvents. However, it was found to exhibit neurotoxicity, reproductive toxicity, and hepatotoxicity in rodents and neurotoxicity in human. However, the mechanisms underlying the toxicities of 1-BP remain elusive. The present study investigated the role of oxidative stress in 1-BP-induced hepatotoxicity using nuclear factor erythroid 2-related factor 2 (Nrf2)-null mice. Groups of 24 male Nrf2-null mice and 24 male wild… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

Report on carcinogens monograph on 1-bromopropane.

  • Report on carcinogens. Monograph on ...
  • 2013
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Toxicological profile for 1-Bromopropane

VIEW 3 EXCERPTS
CITES METHODS & BACKGROUND

Protective Potential of the Glutathione Peroxidase-1 Gene in Abnormal Behaviors Induced by Phencyclidine in Mice

The-Vinh Tran, Eun-Joo Shin, +9 authors Hyoung-Chun Kim
  • Molecular Neurobiology
  • 2016