Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer.

@article{Khor2008IncreasedSO,
  title={Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer.},
  author={Tin Oo Khor and M N Huang and Auemduan Prawan and Yue Liu and Xingpei Hao and Si-wang Yu and William Ka Lung Cheung and Jefferson Y Chan and B. Somasekhara Reddy and Chung S Yang and David Cheng},
  journal={Cancer prevention research},
  year={2008},
  volume={1 3},
  pages={187-91}
}
The nuclear factor-erythroid 2-related factor 2 (Nrf2) plays a critical role in protecting various tissues against inflammation, which is a potential risk factor for colorectal and other cancers. Our previously published mouse model work showed that Nrf2 helps protect against dextran sulfate sodium (DSS)-induced colitis/inflammation, and others have shown that Nrf2 helps protect against inflammation-associated colorectal carcinogenesis (aberrant crypt foci). The present study extended these… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 90 extracted citations

Similar Papers

Loading similar papers…