Increased susceptibility for aspergillosis and post-transplant immune deficiency in patients with gene variants of TLR4 after stem cell transplantation.

@article{Koldehoff2013IncreasedSF,
  title={Increased susceptibility for aspergillosis and post-transplant immune deficiency in patients with gene variants of TLR4 after stem cell transplantation.},
  author={Michael Koldehoff and Dietrich W. Beelen and Ahmet H. Elmaagacli},
  journal={Transplant infectious disease : an official journal of the Transplantation Society},
  year={2013},
  volume={15 5},
  pages={533-9}
}
INTRODUCTION Toll-like receptors (TLRs) detect invading pathogens through several pattern-recognition mechanisms and play a central role in the regulation of the immune system. In allogeneic hematopoietic stem cell transplantation (HSCT), the frequent opportunistic fungal infections remain an important cause of mortality and morbidity in these highly immunocompromised patients. METHODS We analyzed 154 patients after allogeneic HSCT for acute leukemia for TLR4 gene variants 1063A/G (D299G) and… CONTINUE READING

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