Increased superoxide in heart failure: a biochemical baroreflex gone awry.

@article{Mnzel1999IncreasedSI,
  title={Increased superoxide in heart failure: a biochemical baroreflex gone awry.},
  author={Thomas F. M{\"u}nzel and David G Harrison},
  journal={Circulation},
  year={1999},
  volume={100 3},
  pages={216-8}
}
I ncreased peripheral vascular resistance is a hallmark of advanced chronic congestive heart failure (CHF) and contributes to the phenomenon of “increased afterload” that complicates this condition. Multiple factors probably underlie this phenomenon, including increased water and sodium content of the vasculature, increased neurohormonal activation, and intrinsic abnormalities of the vasculature. 1 During the past decade, it has also been shown that endothelium-dependent vasodilation is… CONTINUE READING

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