Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals

@article{Befroy2008IncreasedSO,
  title={Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals},
  author={Douglas E. Befroy and Kitt F. Petersen and Sylvie Dufour and Graeme F. Mason and Douglas L. Rothman and Gerald I. Shulman},
  journal={Proceedings of the National Academy of Sciences},
  year={2008},
  volume={105},
  pages={16701 - 16706}
}
Endurance exercise training is accompanied by physiological changes that improve muscle function and performance. Several studies have demonstrated that markers of mitochondrial capacity are elevated, however, these studies tend to be performed ex vivo under conditions that yield maximal enzyme activities or in vivo but monitoring the response to exercise. Therefore, it is unclear whether basal mitochondrial metabolism is affected by exercise training. To explore whether resting muscle… Expand
Mitochondrial Coupling and Contractile Efficiency in Humans with High and Low V˙O2peaks.
TLDR
The findings reveal that mitochondrial and contractile efficiencies are unaltered by several years of endurance training in young adults, and the training-induced improvement in mitochondrial energetic capacity appears to be independent from changes in mitochondrial coupling. Expand
Mitochondria express enhanced quality as well as quantity in association with aerobic fitness across recreationally active individuals up to elite athletes.
TLDR
Mitochondrial-specific respiration capacities during β-oxidation, maximal oxidative phosphorylation, and electron transport system capacity all correspondingly improve with aerobic capacity, independent of mitochondrial content in human skeletal muscle. Expand
Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans.
  • D. Pesta, F. Hoppel, +7 authors E. Gnaiger
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2011
TLDR
Key mitochondrial adaptations were similar after endurance and strength training, regardless of normoxic or hypoxic exercise, and the limitation of flux by the phosphorylation system was diminished after training. Expand
Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptations.
TLDR
This study shows that mitochondrial uncoupling induces several skeletal muscle adaptations, highlighting the role of mitochondrial coupling as a critical factor for maximal exercise capacities. Expand
Impact of various exercise modalities on hepatic mitochondrial function.
TLDR
Four weeks of exercise training, regardless of exercise modality, significantly increased hepatic mitochondrial respiration and evoked other unique improvements in mitochondrial metabolism that do not appear to be dependent on increases in mitochondrial content. Expand
Maximal oxidative capacity during exercise is associated with skeletal muscle fuel selection and dynamic changes in mitochondrial protein acetylation.
TLDR
Using metabolomic and proteomic profiling, it is shown that HCR efficiently oxidize fatty acids and branched-chain amino acids, sparing glycogen and reducing accumulation of short- and medium-chain acylcarnitines. Expand
The use of blood-flow restriction to enhance high-intensity endurance performance and skeletal muscle adaptation
TLDR
The findings from these studies imply that post-exercise BFR does not increase mitochondrial content, but although there was no increase in skeletal muscle capillarity, there were suggestions thatpost-ex exercise BFR could elicit an enhanced angiogenic stimulus when undertaken with higher training volumes and could subsequently increase performance. Expand
Exercise Training Induces Mitochondrial Biogenesis and Glucose Uptake in Subcutaneous Adipose Tissue Through eNOS-Dependent Mechanisms
TLDR
It is observed that swim training increases mitochondrial biogenesis, mitochondrial DNA content, and glucose uptake in subcutaneous adipose tissue of WT but not eNOS−/− mice after a swim training period, and in vitro effects of NO on mouse 3T3-L1 and human sub cutaneous adiposity–derived adipocytes after a chronic treatment with an NO donor: diethylenetriamine-NO (DETA-NO). Expand
Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity
TLDR
The present review analyses the effects of exercise in the modulation of mitochondrial physiology, examining distinct proposed mechanisms targeting mitochondria and potentially responsible tissue boosting and consequent defect rescuing and the emerging role of epigenetic-based contribution to these cross-tolerance effects is addressed. Expand
High-intensity interval training increases in vivo oxidative capacity with no effect on P(i)→ATP rate in resting human muscle.
TLDR
This novel analysis of resting and maximal high-energy phosphate kinetics in vivo in response to HIT provides evidence that distinct aspects of human skeletal muscle metabolism respond differently to this type of training. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 61 REFERENCES
Effects of acute and chronic endurance exercise on mitochondrial uncoupling in human skeletal muscle
TLDR
UCP3 protein and UCR decrease after endurance training when related to mitochondrial volume, which may prevent excessive basal thermogenesis and the mechanism needs to be further explored. Expand
Endurance training induces muscle-specific changes in mitochondrial function in skinned muscle fibers.
TLDR
It is suggested that training induces muscle-specific adaptations of mitochondrial function and that a change in the intrinsic sensitivity of mitochondria to ADP could at least partly explain the tighter integration of ATP and demand commonly observed after training. Expand
Adaptation of mitochondrial ATP production in human skeletal muscle to endurance training and detraining.
TLDR
Both MAPR and mitochondrial enzyme activities are shown to increase with endurance training and to decrease with detraining. Expand
Effect of endurance training on oxidative and antioxidative function in human permeabilized muscle fibres
TLDR
After endurance training, the relative increase in maximal muscle fibre respiration exceeds that of whole-body oxygen uptake and the sensitivity of mitochondrial respiration to ADP decreases, and the impairment of oxidative function in skinned muscle fibres by ROS remains unchanged. Expand
Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle.
  • J. Holloszy
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1967
TLDR
The increase in electron transport capacity was associated with a concomitant rise in the capacity to produce adenosine triphosphate, which may partially account for the increase in aerobic work capacity that occurs with regularly performed, prolonged exercise. Expand
Control of phosphocreatine resynthesis during recovery from exercise in human skeletal muscle
TLDR
It is shown that the approximately exponential recovery kinetics of ADP and PCr imply that the rate of PCr resynthesis has a hyperbolic dependence on [ADP] but remains approximately linear with respect to the concentration of orthophosphate. Expand
Adaptations of skeletal muscle to endurance exercise and their metabolic consequences.
  • J. Holloszy, E. Coyle
  • Medicine
  • Journal of applied physiology: respiratory, environmental and exercise physiology
  • 1984
TLDR
The major metabolic consequences of the adaptations of muscle to endurance exercise are a slower utilization of muscle glycogen and blood glucose, a greater reliance on fat oxidation, and less lactate production during exercise of a given intensity. Expand
Control of the rate of phosphocreatine resynthesis after exercise in trained and untrained human quadriceps muscles
TLDR
Findings suggest the validity of the use oftc at an end-exercise PCr:(PCr + Pi) ratio of more than 0.5 as a stable index of muscle oxidative capacity and the correlation between local and general aerobic capacity in endurance-trained runners. Expand
Endurance training in humans: aerobic capacity and structure of skeletal muscle.
TLDR
Results indicate that despite disparate relative changes the absolute change in aerobic capacity at the local level (maintained power) can account for the increase in aerobic Capacity observed at the general level (VO2max). Expand
Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism.
TLDR
It is demonstrated that endurance exercise provokes subpopulation-specific changes in mitochondrial function that are characterized by enhanced fatty acid oxidation and modified CPT1beta-malonyl-CoA dynamics. Expand
...
1
2
3
4
5
...