Increased subepithelial vascularization and VEGF expression reveal potentially malignant changes in human oral mucosa lesions.

@article{Gandolfo2011IncreasedSV,
  title={Increased subepithelial vascularization and VEGF expression reveal potentially malignant changes in human oral mucosa lesions.},
  author={Mariana Silvia Gandolfo and Alicia Keszler and Hector Eduardo Lanfranchi and Mar{\'i}a Elina Itoiz},
  journal={Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics},
  year={2011},
  volume={111 4},
  pages={486-93}
}
OBJECTIVE The objective of this study was to provide evidence that the magnitude of angiogenesis induced by oral mucosa epithelium with potentially malignant lesions is related to the degree of epithelial aggressiveness. METHODS AND RESULTS We evaluated 96 biopsies that included: (1) leukoplakia with and without dysplasia, (2) nontumoral borders adjacent to squamous cell carcinomas with and without dysplasia, and (3) normal oral mucosa. Number, size, and localization of vessels labeled… CONTINUE READING
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