Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins.

@article{Nilsson2007IncreasedSM,
  title={Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins.},
  author={Anna Nilsson and Karl Sk{\"o}ld and Benita Sj{\"o}gren and Marcus Svensson and Johan Pierson and Xiaoqun Zhang and Richard M Caprioli and Jos Buijs and Bj{\"o}rn Persson and Per Svenningsson and Per E. Andr{\'e}n},
  journal={Journal of proteome research},
  year={2007},
  volume={6 10},
  pages={3952-61}
}
FKBP-12, a 12 kDa FK506-binding protein (neuroimmunophilin), acts as a receptor for the immunosuppressant drug FK506. Neuroimmunophilins, including FKBP-12, are abundant in the brain and have been shown to be involved in reversing neuronal degeneration and preventing cell death. In this report, we have utilized several analytical techniques, such as in situ hybridization, Western blotting, two-dimensional gel electrophoresis, and liquid chromatography electrospray tandem mass spectrometry to… CONTINUE READING